Retrospective birth dating of cells in humans

Nonetheless, for large homogeneous populations of cells, an average age can be estimated.

The authors leave open the possibility that adult neurogenesis occurs in brain regions that were not examined in the study.Methodological flaws have been proposed as explanations for putative false positive and false negative data on this subject (13,26).The development and application of new methods is clearly needed to resolve the debate about adult neurogenesis in neocortex and other “non-neurogenic” brain regions.Using this approach, the average age of cells in two regions of the adult human brain autopsy tissue—the cerebellum and occipital cortex—were estimated.The authors found that cells in the occipital cortex were younger than cells in the cerebellum, but when neurons and non-neurons were separated, the occipital cortex neurons were the oldest, almost as old as the individual.

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